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List of User Publications

The publications listed below feature AquaFlux & Epsilon measurements in diverse areas of research. Click the titles to read abstracts and/or download texts.

Look also at the Library for more publications associated with Biox equipment.


Psoriasis-associated Late Cornified Envelope (LCE) Proteins have Antibacterial Activity
H. Niehues, L.C. Tsoi, D.A. van der Krieken, P.A.M. Jansen, M.A.W. Oortveld, D. Rodijk-Olthuis, I.M.J.J. van Vlijmen, W.J.A.J. Hendriks, R.W. Helder, J.A. Bouwstra, E.H. van den Bogaard, P.E. Stuart, R.P. Nair, J.T. Elder, P.L.J.M. Zeeuwen & J. Schalkwijk.J Invest Dermatol, pii: S0022-202X(17)31650-0, 2017. [Epub ahead of print].

Topical Bioavailability of Diclofenac from Locally-acting, Dermatological Formulations
S.F. Cordery, A. Pensado, W.S. Chiu, M.Z. Shehab, A.L. Bunge, M.B. Delgado-Charro & R.H. Guya. International Journal of Pharmaceutics, 529(1-2), 55-64, 2017.

Beauty in Baobab: A Pilot Study of the Safety and Efficacy of Adansonia Digitata Seed Oil
B.M. Komane, I. Vermaak, G.P.P. Kamatou, B. Summers, A.M. Viljoen. Revista Brasileira de Farmacognosia, 27(1), 1-8, 2017.

Epidermal Equivalents of Filaggrin Null Keratinocytes do not show impaired Skin Barrier Function
H. Niehues, J. Schalkwijk, I.M.J.J. van Vlijmen-Willems, D. Rodijk-Olthuis, M.M. van Rossum, E. Wladykowski, J.M. Brandner, E.H.J. van den Bogaard, P.L.J.M. Zeeuwen. Journal of Allergy and Clinical Immunology, 139(6), 1979-1981, 2017.

Estimation of Sweat Rates During Cycling Exercise by Means of the Closed Chamber Condenser Technology
P. Clarys, R. Clijsen, A.O. Barel, R. Schouteden, B. van Olst, D. Aerenhouts. Skin Res Technol, 23(1), 30-35, 2017.

Molecular Signatures Order the Potency of Topically Applied Anti-inflammatory Drugs in Patients with Atopic Dermatitis
E. Guttman-Yassky, B. Ungar, K. Malik, D. Dickstein, M. Suprun, Y.D. Estrada, H. Xu, X. Peng, M. Oliva, D. Todd, T. Labuda, M. Suarez-Farinas & R. Bissonnette. Journal of Allergy and Clinical Immunology, in Press 2017.


Clinical, Biophysical and Immunohistochemical Analysis of Skin Reactions to Acute Skin Barrier Disruption - a Comparative Trial between Participants with Sensitive Skin and those with Nonsensitive Skin
R.J.H. Richters, N.E. Uzunbajakava, D. Falcone, J.C.M. Hendriks, E.J. Jaspers, P.C.M. van de Kerkhof & P.E.J. van Erp. Br J Dermatol 174(5), 1126-33, 2016.

Drug Permeation and Barrier Damage in Leishmania-infected Mouse Skin
K. Van Bocxlaer, V. Yardley, S. Murdan & S.L. Croft. J Antimicrob Chemother, 71(6), 1578-85, 2016.

A Functional Mechanistic Study of the Effect of Emollients on the Structure and Function of the Skin Barrier
S.G. Danby, J. Chalmers, K. Brown, H.C. Williams & M.J. Cork. Br J Dermatol. 175(5), 1011-1019, 2016.

Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
P. Bianchi, J. Theunis, C. Casas, C. Villeneuve, A. Patrizi, C. Phulpin, A. Bacquey, D. Redoulès, V. Mengeaud & A.M. Schmitt. Pediatr Dermatol, 33(2), 165-71, 2016.

Fragility of Epidermis in Newborns, Children and Adolescents
U. Blume-Peytavi, J. Tan, D. Tennstedt, F. Boralevi, G. Fabbrocini, A. Torrelo, R. Soares-Oliveira, M. Haftek, A.B. Rossi, M.D. Thouvenin, J. Mangold, M.F. Galliano, H. Hernandez-Pigeon, M.F. Aries, C. Rouvrais, S. Bessou-Touya, H. Duplan, N. Castex-Rizzi, V. Mengeaud, P.J. Ferret, E. Clouet, M. Saint Aroman, C. Carrasco, C. Coutanceau, B. Guiraud, S. Boyal, A. Herman, H. Delga, K. Biniek & R. Dauskardt. J Eur Acad Dermatol Venereol, 30(S4), 3-56, 2016.

Gram-positive Anaerobe Cocci are Underrepresented in the Microbiome of Filaggrin-deficient Human Skin
P.L.J.M. Zeeuwen, T.H.A. Ederveen, D.A. van der Krieken, H. Niehues, J. Boekhorst, S. Kezic, D.A.T. Hanssen, M.E. Otero, I.M.J.J. van Vlijmen-Willems, D. Rodijk-Olthuis, D. Falcone, E.H.J. van den Bogaard, M. Kamsteeg, H.D. de Koning, M.E.J. Zeeuwen-Franssen, M.A.M. van Steensel, M. Kleerebezem, H.M. Timmerman, S.A.F.T. van Hijum & J. Schalkwijk. Journal of Allergy and Clinical Immunology, in Press, 2016.

Facial Skin Pigmentation is not related to Stratum Corneum Cohesion, Basal Transepidermal Water Loss, Barrier Integrity and Barrier Repair
R. Voegeli, A.V. Rawlings & B. Summers. IJCS, 37(2), 241-52, 2015.

Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study)
A. Cooke, M.J. Cork, S. Victor, M. Campbell, S. Danby, J. Chittock & T Lavender. Acta Derm Venereol. 96(3), 323-30, 2016.

Responses to Sodium Dodecyl Sulphate as an in vivo Human Model to Study the Pathomechanisms underlying Sensitive Skin
R.J.H. Richters, J.C. Hendriks, N.E. Uzunbajakava, L.D. Janssen, D. Falcone, P.E. van Erp & P.C. van de Kerkhof. Exp Dermatol, 25(5), 407-9, 2016.

Clinical, Biophysical, Immunohistochemical, and in vivo Reflectance Confocal Microscopy Evaluation of the Response of Subjects with Sensitive Skin to Home-use Fractional Non-ablative Photothermolysis Device
R.J. Richters, L. Hoogedoorn, N.E. Uzunbajakava, L.D. Janssen, A.M. Tom Nuijs, P.E. van Erp & P.C. van de Kerkhof. Lasers Surg Med, 48(5), 474-82, 2016.

Development of Stratum Corneum Chymotrypsin-like Protease Activity and Natural Moisturising Factors from Birth to 4 Weeks of Age compared to Adults
J. Chittock, A. Cooke, T. Lavender, K. Brown, A. Wigley, S. Victor, M.J. Cork & S.G. Danby. Br J Dermatol 175(4), 713-720, 2016.

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin
S.G.Danby, K. Brown, T. Higgs-Bayliss, J. Chittock, L. Albenali & M.J. Cork. Skin Pharmacol Physiol 29(3), 135-147, 2016.

A Fundamental Investigation into Aspects of the Physiology and Biochemistry of the Stratum Corneum in Subjects with Sensitive Skin
N. Raj, R. Voegeli, A.V. Rawlings, S. Doppler, D. Imfeld, M.R. Munday & M.E. Lane. IJCS, 1-9, 2016.

Association between Domestic Water Hardness, Chlorine, and Atopic Dermatitis Risk in Early Life: A Population-based Cross-sectional Study
M.R. Perkin, J. Craven, K. Logan, D. Strachan, T. Marrs, S. Radulovic, L.E. Campbell, S.F. MacCallum, W.H. Irwin McLean, G. Lack, C. Flohr. Journal of Allergy and Clinical Immunology, 138(2), 509-16, 2016.

An Investigation of how Fungal Infection influences Drug Penetration through Onychomycosis Patient's Nail Plates
W.J. McAuley, S.A. Jones, M.J. Traynor, S. Guesné, S. Murdan, M.B. Brown. European Journal of Pharmaceutics and Biopharmaceutics, 102(5), 178-184, 2016.

Staphylococcus Aureus Density on Lesional and Nonlesional Skin is strongly associated with Disease Severity in Atopic Dermatitis
M. Tauber, S. Balica, C-Y. Hsu, C. Jean-Decoster, C. Lauze, D. Redoules, C. Viod, A-M. Schmitt, G. Serre, M. Simon & C.F. Paul. Journal of Allergy and Clinical Immunology, 137(4), 1272-4, 2016.

Epidermal Equivalents of Filaggrin Null Keratinocytes do not show Impaired Skin Barrier Function
H. Niehues, J. Schalkwijk, I.M.J.J. van Vlijmen-Willems, D. Rodijk-Olthuis, M.M. van Rossum, E. Wladykowski, J.M. Brandner, E.H.J. van den Bogaard & P.L.J.M. Zeeuwen. Journal of Allergy and Clinical Immunology, In Press, 2016.

Ibuprofen Delivery into and through the Skin from Novel Oxidized Cellulose-based Gels and conventional Topical Formulations
D. Celebi, R.H. Guy, K.J. Edler & J.L. Scott, Int J Pharm, 514(1), 238-243, 2016.


An in vitro Skin Penetration Model for Compromised Skin: Estimating Penetration of Polyethylene Glycol [14C]-PEG-7 Phosphate
S. Dey, H. Rothe, L. Page, R. O'Connor, S. Farahmand, F. Toner, R. Marsh, K. Wehmeyer & S. Zhou. Skin Pharmacol Physiol, 28(1), 12-21, 2015.

A novel Continuous Colour Mapping Approach for Visualization of Facial Skin Hydration and Transepidermal Water Loss for four Ethnic Groups
R. Voegeli, A.V. Rawlings, P. Seroul and B. Summers, IJCS, 37(6), 595-605, 2015.

Development and in vitro Evaluation of Lipid Nanoparticle-based Dressings for Topical Treatment of Chronic Wounds
G. Gainza, W.S. Chu, R.H. Guy, J.L. Pedraz, R.M. Hernandez, B. Delgado-Charro & M. Igartua. Int J Pharm, 490(1-2), 404-11, 2015.

The Occlusion Effects in Capacitive Contact Imaging for in vivo Skin Damage Assessments
W. Pan, X. Zhang, M. Lane and P. Xiao. IJCS, 37(4), 395-400, 2015.

Facial Skin Pigmentation is not related to Stratum Corneum Cohesion, Basal Transepidermal Water Loss, Barrier Integrity and Barrier Repair
R. Voegeli, A.V. Rawlings & B. Summers. IJCS, 37(2), 241-52, 2015.

Safety and Efficacy of Sclerocarya Birrea (A.Rich.) Hochst (Marula) oil: A Clinical Perspective
B. Komane, I. Vermaak, B. Summers & A. Viljoen. Journal of Ethnopharmacology 176, 327-35, 2015.

Simultaneous Determination of Active Component and Vehicle Penetration from F-DPPC Liposomes into Porcine Skin Layers
D-S. Mahrhauser, G. Reznicek, S. Gehrig, A. Geyer, M. Ogris, R. Kieweler & C. Valenta. European Journal of Pharmaceutics and Biopharmaceutics, 97(A), 90-5, 2015.

Dilution of semi-solid creams: influence of various production parameters on rheological properties and skin penetration
C. Nagelreiter, E. Kratochvilova & C. Valenta. Int J Pharm, 478(2), 429-38, 2015.

Optimisation of a dosing regime for a topical skin protectant (barrier cream)
R.P. Chilcott, J. Larner, H. Matar, S. Kansagra, B. Theivendran, V.A. Viegas & V.S. Goldman. Cutan Ocul Toxicol, 19, 1-8, 2015.

Efficient Nanoparticle-mediated needle-free Transcutaneous vaccination via Hair Follicles requires Adjuvantation
A. Mittal, K. Schulze, T. Ebensen, S. Weißmann, S. Hansen, C.M. Lehr & C.A. Guzmán. Nanomedicine, 11(1), 147-54, 2015.

Topical Delivery of Acetyl Hexapeptide-8 from different Emulsions: Influence of Emulsion Composition and Internal Structure
M. Hoppel, G. Reznicek, H. Kählig, H. Kotisch, G.P. Resch & C. Valenta. European Journal of Pharmaceutical Sciences, 68, 27–35, 2015.

Development of a Cumulative Irritation Model for Incontinence-associated Dermatitis
J. Larner, H. Matar, V.S. Goldman & R.P. Chilcott. Arch Dermatol Res, 307(1), 39-48, 2015.

Topical Formulation and Dermal Delivery of Active Phenolic Compounds in the Thai Medicinal Plant Clerodendrum Petasites S. Moore
P. Thitilertdecha, M.G. Rowan & R.H. Guy. Int J Pharm, 478(1), 39–45, 2015.


The Effects of Heat on Skin Barrier Function and in vivo Dermal Absorption
G. Oliveira, J.C. Leverett, M. Emamzadeh & M.E. Lane. Int J Pharm, 464(1–2), 145-151, 2014.

Simultaneous analysis of skin penetration of surfactant and active drug from fluorosurfactant-based microemulsions
D. Mahrhauser, M. Hoppel, J. Schöll, L. Binder, H. Kählig & C. Valenta. Eur J Pharm Biopharm, 88(1), 34–39, 2014.

Dermal Permeation of 2-Hydroxypropyl Acrylate, a Model Water-Miscible Compound: Effects of Concentration, Thermodynamic Activity and Skin Hydration
H.F. Frasch, A.M. Barbero, G.S. Dotson & A.L. Bunge. International Journal of Pharmaceutics, 460(1-2), 240–247, 2014.

Methods and Models for the Investigation of the Uptake of Nanoparticles into Hair Follicles
A.S. Raber. Universität des Saarlandes, 2014.

Influence of Lidocaine Hydrochloride and Penetration Enhancers on the Barrier Function of Human Skin
K. Hirata, D. Mohammed, J. Hadgraft & M.E. Lane. International Journal of Pharmaceutics, 477(1-2), 416–420, 2014.

Time Course of Skin Features and Inflammatory Biomarkers after Liquid Sulfur Mustard Exposure in SKH-1 Hairless Mice
S. Mouret, J. Wartelle, M. Batal, S. Emorine, M. Bertoni, T. Poyot, C. Cléry-Barrauda, N. E. Bakdouri, A. Peinnequin, T. Douki & I. Boudry. Toxicol Lett, 232(1), 68-78, 2014.

Ultra-pure Soft Water Improves Skin Barrier Function in Children with Atopic Dermatitis: A Randomized, Double-blind, Placebo-controlled, Crossover Pilot Study
Y. Togawa, N. Kambe, N. Shimojo, T. Nakano, Y. Sato, H. Mochizuki, A. Tanaka, H. Matsuda & H. Matsue. J Dermatol Sci, 76(3), 269–271, 2014.

Water Diffusion through Stratum Corneum
B. Imhof & P. Xiao. Computational Biophysics of the Skin (Editor: B. Querleux), 11, 333-352, Pan Stanford Publishing 2014. Print ISBN: 9789814463843 eBook ISBN: 9789814463850.

Influence of the Composition of Monoacyl Phosphatidylcholine Based Microemulsions on the Dermal Delivery of Flufenamic Acid
M. Hoppel, H. Ettl, E. Holper & C. Valenta. International Journal of Pharmaceutics, 475(1–2), 156–162, 2014.

Silicones as Nonocclusive Topical Agents
K. De Paepe, A. Sieg M. Le Meur & V. Rogiers. Skin Pharmacol Physiol 27, 164-171, 2014.

Influence of Skin Penetration Enhancers on Skin Barrier Function and Skin Protease Activity
D. Mohammed, K. Hirata, J. Hadgraft & M.E. Lane. European Journal of Pharmaceutical Sciences, 51, 118–122, 2014.

Characterisation of a Novel Flexing Diffusion Cell (CutaFlex TM) for Assessing Dermal Exposure to Nanoparticles
V.A. Viegas. Vanessa. PhD Thesis, University of Hertfordshire, 2014.

Dermal Permeation of 2-Hydroxypropyl Acrylate, a Model Water-miscible Compound: Effects of Concentration, Thermodynamic Activity and Skin Hydration
H.F. Frasch, A.M. Barbero, G.S. Dotson & A.L. Bunge. Int J Pharm, 460(1-2), 240-7, 2014.

Evaluation of the Barrier Function of Skin using Transepidermal Water Loss (TEWL)
B. Imhof & G. McFeat. Handbook of Cosmetic Science and Technology, 4th Edition (Editors: A.O. Barel, M. Paye& H.I. Maibach), 11, 131–140, CRC Press 2014. Print ISBN: 978-1-84214-564-7, eBook ISBN: 978-1-84214-565-4.

Tranexamic Acid Accelerates Skin Barrier Recovery and Upregulates Occludin in Damaged Skin
C. Yuan, X-M. Wang, L-J. Yang & P.L. Wu. Int J Dermatol, 53(8), 959-65, 2014.

TEWL, Closed-Chamber Methods: AquaFlux and VapoMeter
B. Imhof, P. Xiao & I. Angelova-Fischer. Non Invasive Diagnostic Techniques in Clinical Dermatology (Editors: E. Berardesca, H.I. Maibach & K-P. Wilhelm), 345-352, Springer Verlag 2014. Print ISBN: 978-3-642-32108-5, Online ISBN 978-3-642-32109-2.

Quantification of Nanoparticle Uptake into Hair Follicles in Pig Ear and Human Forearm
A.S. Raber, A. Mittal, J. Schäfer, U. Bakowsky, J. Reichrath, T. Vogt, U.F. Schaefer, S. Hansen & C.-M. Lehr. Journal of Controlled Release, 179, 25-32, 2014.

Atopic Dermatitis and Disease Severity are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants
C. Flohr, M. Perkin, K. Logan, T. Marrs, S. Radulovic, L.E. Campbell, S.F. MacCallum, W.H. Irwin McLean & G. Lack. J Invest Dermatol, 134(2), 345-50, 2014.


Topical Efficacy of Dimercapto-chelating Agents against Lewisite-induced Skin Lesions in SKH-1 Hairless Mice
S. Mouret, J. Wartelle, S. Emorine, M. Bertoni, N. Nguon, C. Cléry-Barraud, F. Dorandeu & I. Boudry. Toxicology and Applied Pharmacology, 272(2), 291–298, 2013.

Membrane Solvent Penetration Measurements Using Contact Imaging
P. Xiao, H. Abdalghafor and M.E. Lane, Advances in Dermatological Sciences, 355-360, 2013. Print ISBN: 978-1-84973-398-4, PDF eISBN: 978-1-84973-463-9

Influence of Various Environmental Parameters on Sweat Gland Activity
R.L. McMullen, T. Gillece, G. Lu, D. Laura & S. Chen. J Cosmet Sci, 64(4), 243-60, 2013.

Compared Evaluation of Botulinum Toxin A and a Cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis
M. Streker, S. Lübberding & M. Kerscher. JCDSA 3(3), 190-6, 2013.

The Impact of Surface Loading and Dosing Scheme on the Skin Uptake of Fragrances
F. Berthaud, B. Smith & M. Boncheva. Toxicology in Vitro, 27(8), 2169–2174, 2013.

Mechanical Tomography of Human Corneocytes with a Nanoneedle
J.D. Beard, R.H. Guy & S.N. Gordeev. J Invest Dermatol, 133(6), 1565-71, 2013.

Improvement of Skin Barrier Function in Atopic Dermatitis Patients with a new Moisturizer containing a Ceramide Precursor
E. Simpson, A. Böhling, S. Bielfeldt, C. Bosc & N. Kerrouche. J Dermatolog Treat, 24(2), 122-5, 2013.

Enhanced Sonophoretic Delivery of 5-aminolevulinic acid: Preliminary Human Ex Vivo Permeation Data
G. Krishnan, J.E. Grice, M.S. Roberts, H.A. Benson & T.W. Prow. Skin Res Technol, 19(1), e283-9, 2013.

International Guidelines for the In-vivo Assessment of Skin Properties in Non-clinical Settings: Part 2. Transepidermal Water Loss and Skin Hydration
J. du Plessis, A. Stefaniak, F. Eloff, S.John, T. Agner, T-C. Chou, R. Nixon, M. Steiner, A. Franken, I. Kudla & L. Holness. Skin Res Tech, 19(3), 265-78, 2013.

Temporal and Spatial Features of the Formation of DNA Adducts in Sulfur Mustard-exposed Skin
M. Batal, I. Boudry, S. Mouret, J. Wartelle, S. Emorine, M. Bertoni, I. Bérard, C. Cléry-Barraud & T. Douki. Toxicology and Applied Pharmacology, 273(3), 644-650, 2013.

The Effect of a Novel Zinc Pyrithione Hair Care System on Female Scalp Condition
L. Weddell, C. Jones, F. Baines & J. Matheson. Journal of the American Academy of Dermatology, 68(4), Supplement 1: Poster Abstracts, AB109, 2013.

The Effect of Formulation on the Penetration of Coated and Uncoated Zinc Oxide Nanoparticles into the Viable Epidermis of Human Skin In-vivo
V.R. Leite-Silva, M. Le Lamera, W.Y. Sanchez, D.C. Liu, W.H. Sanchez, I. Morrow, D. Martin, H.D.T. Silva, T.W. Prowd, J.E. Grice & M.S. Roberts. Eur J Pharm Biopharm, 84(2), 297-308, 2013.

Influence of Niacinamide Containing Formulations on the Molecular and Biophysical Properties of the Stratum Corneum
D. Mohammed, J.M. Crowther, P.J. Matts, J. Hadgraft & M.E. Lane. Int J Pharm, 441(1-2), 192-201, 2013.

Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care
S.G. Danby, T. AlEnezi, A. Sultan, T. Lavender, J. Chittock, K. Brown & M.J. Cork. Pediatr Dermatol, 30(1), 42–50, 2013.

Sulfur Mustard Cutaneous Injury Characterization based on SKH-1 Mouse Model: Relevance of Non-invasive Methods in terms of Wound Healing Process Analyses
C. Cléry-Barraud, N. Nguon, V. Vallet, C. Sentenac, E. Four, C. Arlaud, D. Coulon & I. Boudry. Skin Res Tech, 19(1), e146–e156, 2013.

Influence of Drug Content, Type of Semi-solid Vehicle and Rheological Properties on the Skin Penetration of the Model Drug Fludrocortisone Acetate
C. Nagelreiter, S. Raffeiner, C. Geyerhofer, V. Klang & C. Valenta. International Journal of Pharmaceutics, 448(1), 305–312, 2013.

Skin Integrity Testing and Monitoring of In-vitro Tape Stripping by Capacitance-based Sensor Imaging
V. Klang, J.C. Schwarz, S. Haberfeld, P. Xiao, M. Wirth & C. Valenta. Skin Res Tech, 19(1), e259–e272, 2013.

In-vivo Barrier Challenge and Initial Recovery in Human Facial Skin
M. Gorcea, J. Hadgraft, D.J. Moore & M.E. Lane. Skin Res Tech, 19(1), e375–e382, 2013.


The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and their Potential Toxic Metabolic Consequences
D.C. Liu, A.P. Raphael, D. Sundh, J.E. Grice, H.P. Soyer, M.S. Roberts & T.W. Prow. J Nanomat, in press, 2012.

De la Physiologie à la Répartition: Adaptations Climatiques et Sensibilité Thermique chez une Relique Glaciaire
M. Guillon. PhD Thesis, Université de Poitiers, 2012.

In vivo Stratum Corneum Over-hydration and Water Diffusion Coefficient Measurements Using Opto-Thermal Radiometry and TEWL Instruments
P. Xiao, W. Wong, A.M. Cottenden & R.E. Imhof. IJCS, 34(4), 328–331, 2012.

Novel Imaging Method to Quantify Stratum Corneum in Dermatopharmacokinetic Studies
L.M. Russell & R.H. Guy. Pharm Res, 29(9), 2389-97, 2012.

Effect of Microneedle Treatment on the Skin Permeation of a Nanoencapsulated Dye
Y.A. Gomaa, L.K. El-Khordagui, M.J. Garland, R.F. Donnelly, F. McInnes & V.M. Meidan. J Pharm Pharmacol, 64(11), 1592–1602, 2012.

Passive and Iontophoretic Transdermal Delivery of Phenobarbital: Implications in Paediatric Therapy
A. Djabri, R.H. Guy, M.B. Delgado-Charro. Int J Pharmaceut, 435(1), 76-82, 2012.

Effect on Skin Hydration of using Baby Wipes to clean the Napkin Area of Newborn Babies: Assessor-blinded Randomised Controlled Equivalence Trial
T. Lavender, C. Furber, M. Campbell, S. Victor, I. Roberts, C. Bedwell & M.J. Cork. BMC Pediatr. 12:59, 1-9, 2012.

Evaluation of the Efficacy of Orange Roughy (Hoplostetbus Atlanticus) Oil in Subjects with Dry Skin
N. Domoto, T. Koriyama, B-S. Chu & T. Tsuji. IJCS, 34(4), 322–327, 2012.

Two Dimensional Finite Element Modelling for Dynamic Water Diffusion through Stratum Corneum
P. Xiao & R.E. Imhof. Int J Pharmaceut, 435(1), 88–92, 2012.

Ability to Estimate Relative Percutaneous Penetration via a Surrogate Marker – Trans Epidermal Water Loss?
X. Hui, R. Elkeeb, H. Chan & H.I. Maibach. Skin Res Tech, 18(1), 108–13, 2012.

Differences in Susceptibility to Oxidative Stress in the Skin of Japanese and French Subjects and Physiological Characteristics of their Skin
Y. Yamashita, Y. Okano, T. Ngo, P. Buche, A. Sirvent, F. Girard & H. Masaki. Skin Pharmacol Physiol, 25, 78-85, 2012).

Hair and Nail Water-holding Capability Measurements by using Condenser-TEWL Method
P. Xiao, Y. Cui, L.I. Ciortea, E.P. Berg & R.E. Imhof. IJCS, 34(1), 12–16, 2012.

In Vitro vs. In Vivo Tape Stripping: Validation of the Porcine Ear Model and Penetration Assessment of Novel Sucrose Stearate Emulsions
V. Klang, J.C. Schwarz, B. Lenobel, M. Nadj, J. Auböck, M. Wolzt & C. Valenta. Eur J Pharm Biopharm, 80(3), 604-14, 2012.

Skin Kinetics and Dermal Clearance
P. Shashi, N. Anroop, S. Vipin & S. Neelam. IRJP, 3(8), 14-21, 2012.

Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. AAPS J. 14(4), 806-12, 2012.

Effect of Y-Cyclodextrin on the In Vitro Skin Permeation of a Steroidal Drug from Nanoemulsions: Impact of Experimental Setup
V. Klang, S. Haberfeld, A. Hartl & C. Valenta. Int J Pharm, 423(2), 535–542, 2012.


Time-Correlated Single Photon Counting for Simultaneous Monitoring of Zinc Oxide Nanoparticles and NAD(P)H in Intact and Barrier-Disrupted Volunteer Skin
L.L. Lin, J.E. Grice, M.K. Butler, A.V. Zvyagin, W. Becker, T.A. Robertson, H.P. Soyer, M.S. Roberts & T.W. Prow. Pharm Res, 28(11), 2920-30, 2011.

Etablissement d'un modèle canin de rupture chronique de la barrière cutanée
L.M. Perrin. PhD Thesis, Université Claude Bernard, Lyon 2011.

Dynamic In Vivo Mapping of Model Moisturiser Ingress into Human Skin by GARfield MRI
E. Ciampi, M. van Ginkel, P.J. McDonald, S. Pitts, E.Y.M. Bonnist, S. Singleton & A-M. Williamson. NMR in Biomedicine, 24(2), 135–144, 2011.

Gold Nanoparticle Penetration and Reduced Metabolism in Human Skin by Toluene
H.I. Labouta, D.C. Liu, L.L. Lin, M.K. Butler, J.E. Grice, A.P. Raphael, T. Kraus, L.K. El-Khordagui, H.P. Soyer, M.S. Roberts, M. Schneider & T.W. Prow. Pharm Res, 28(11), 2931-44, 2011.

Development and Preliminary Testing of a Standardized Method for Quantifying Excess Water in Over-hydrated Skin using Evaporimetry
M. Fader, S.R. Clark-O'Neill, W.K.R Wong, B. Runeman, A. Farbrot, A.M. Cottenden. Physiological Measurement, 32(3), 305-317, 2011.

Modification of the Conformational Skin Structure by Treatment with Liposomal Formulations and its Correlation to the Penetration Depth of Aciclovir
A. Hasanovic, R. Winkler, G.P. Resch & C. Valenta. Eur J Pharm Biopharm, in press, 79(1), 76-81, 2011.

The Effect of Aqueous Cream BP on the Skin Barrier in Volunteers with a Previous History of Atopic Dermatitis
S.G. Danby, T. Al-Enezi, A. Sultan, J. Chittock, K. Kennedy & M.J. Cork. Brit J Dermatol,165(2), 329-34, 2011.

Influence of Aqueous Cream on Corneocyte Size, Maturity, Skin Protease Activity, Protein Content and Trans-Epidermal Water Loss
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. Brit J Dermatol, 164, 1304–1310, 2011.

Semi-solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems
V. Klang, J.C. Schwarz, N. Matsko, E. Rezvani, N. El-Hagin, M. Wirth & C. Valenta. Pharmaceutics, 3(2), 275-306, 2011.

Infant Skin-cleansing Product versus Water: A Pilot Randomized, Assessor-blinded Controlled Trial
T. Lavender, C. Bedwell, E. O'Brien, M.J. Cork, M. Turner & A. Hart. BMC Pediatrics, 11:35, 2011.

Depth Profiling of Stratum Corneum Biophysical and Molecular Properties
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. Brit J Dermatol, 164(5), 957–965, 2011.

Facilitating in vitro Tape Stripping: Application of Infrared Densitometry for Quantification of Porcine Stratum Corneum Proteins
V. Klang, J.C. Schwarz, A. Hartl & C. Valenta. Skin Pharmacol Physiol, 24(5), 256-268, 2011.

Les adaptations climatiques chez les squamates
A. Dupoué, Master 2 Écophysiologie et Éthologie, Université de Strasbourg (2011).

Visualization, Dermatopharmacokinetic Analysis and Monitoring the Conformational Effects of a Microemulsion Formulation in the Skin Stratum Corneum
R.M. Hathout, S. Mansour, A.S. Geneidi & N.D. Mortada. Journal of Colloid and Interface Science, 354(1), 124-130, 2011.


Assessment of Cumulative Exposure to UVA through Study of Asymmetric Facial Skin Damage
S. Mac-Mary, J-M. Sainthillier, A. Jeudy, C. Sladen, C. Williams, M. Bell & P. Humbert. Clin Interv Aging, 5, 277-284, 2010.

Disposition of Charged Nanoparticles after their Topical Application to the Skin
X. Wu, K. Landfester, A. Musyanovych & R.H. Guy. Skin Pharmacol Physiol, 23(3), 117-123, 2010.

Opto-thermal Radiometry for In-vivo Nail Measurements
P. Xiao, L.I. Ciortea, H. Singh, E.P. Berg & R.E. Imhof. Journal of Physics: Conference Series, 214(1), 012008, 2010.

Effect of Aqueous Cream BP on human stratum corneum in vivo
M. Tsang & R.H. Guy. Brit J Dermatol, 163, 954–958, 2010.

Formulation and Delivery of Topically Applied Drugs for the Treatment of Atopic Eczema and other Related Diseases
M. Tsang, PhD Thesis, University of Bath 2010.

Extraction and Quantification of Amino Acids in Human Stratum Corneum in vivo
J.-P. Sylvestre, C.C. Bouissou, R.H. Guy & M.B. Delgado-Charro. Brit J Dermatol, 163, 458–465, 2010.

Superior Effect of Isostearyl Isostearate on Improvement in Stratum Corneum Water Permeability Barrier Function as Examined by the Plastic Occlusion Stress Test
G. Pennick, S. Harrison, D. Jones & A.V. Rawlings. Int J Cosmet Sci, 32(4), 304–312, 2010.

Filaggrin Loss-of-function Mutations are associated with Early-onset Eczema, Eczema Severity and Transepidermal Water Loss at 3 Months of Age
C. Flohr, K. England, S. Radulovic, W.H.I. McLean, L.E. Campbell, J. Barker, M. Perkin & G. Lack. Brit J Dermatol, 163(6), 1333–1336, 2010.

The Relationship between Transepidermal Water Loss and Skin Permeability
M. Machado, T.M. Salgado, J. Hadgraft & M.E. Lane. Int J Pharm, 384, 73-77, 2010.

Correlation of Transepidermal Water Loss with Skin Barrier Properties in-vitro: Comparison of three Evaporimeters
R. Elkeeb, X. Hui, H. Chan, L. Tien & H.I. Maibach. Skin Res Tech, 16(1), 9–15, 2010.

Effects of Microneedle Length, Density, Insertion Time and Multiple Applications on Human Skin Barrier Function: Assessments by Transepidermal Water Loss
Y.A. Gomaa, D.I.J. Morrow, M.J. Garland, R.F. Donnelly, L.K. El-Khordagui & V.M. Meidan. Toxicology in Vitro, 24(7), 1971-1978, 2010.

Bioengineering and Subjective Approaches to the Clinical Evaluation of Dry Skin
A.J. Byrne. IJCS, 32(6), 410–421, 2010.

Ageing Appearance in China: Biophysical Profile of Facial Skin and its Relationship to Perceived Age
A.E. Mayes, P.G. Murray, D.A. Gunn, C.C. Tomlin, S.D. Catt, Y.B. Wen, L.P. Zhou, H.Q. Wang, M. Catt & S.P. Granger. J Eur Acad Dermatol Venereol. 24(3), 341-8, 2010.

Nanoparticles of Biodegradable Polymers and DPPC Liposomes for Skin Diffusion Studies and Physicochemical Stabilisation of the incorporated Model Drugs
A. Hasanovic, PhD Thesis, University of Vienna, Fakultät für Lebenswissenschaften (2010).


Closed-chamber Transepidermal Water Loss Measurement: Microclimate, Calibration and Performance
R.E. Imhof, M.E.P. De Jesus, P. Xiao, L.I. Ciortea & E.P. Berg. IJCS, 31(2), 97-118, 2009.

4-amidino Benzylamines for Cosmetic and/or Dermatological Use
R. Vögeli, H. Ziegler & M. Gempeler, Patent WO/2009/026949.

An Investigation into the Combination of Low Frequency Ultrasound and Liposomes on Skin Permeability
A. Dahlan, H.O. Alpar & S. Murdan. Int J Pharm, 379, 139-142, 2009.

Transepidermal Water Loss for Probing Full-thickness Skin Barrier Function: Correlation with Tritiated Water Flux, Sensitivity to Punctures and Diverse Surfactant Exposures
E. Elmahjoubi, Y. Frum, G.M. Eccleston, S.C. Wilkinson & V.M. Meidan. Toxicology in Vitro, 23(7), 1429-35, 2009.

In-vivo Transungual Iontophoresis: Effect of DC Current Application on Ionic Transport and on Transonychial Water Loss
J. Dutet, & M.B. Delgado-Charro. Journal of Controlled Release, 140(2), 117-25, 2009.

Measuring Transepidermal Water Loss: Comparative In-vivo Study of Condenser-chamber, Unventilated-chamber and Open-chamber Systems
S. Farahmand, L. Tien, X. Hui & H.I. Maibach. Skin Res Tech, 15(4), 392-398, 2009.

Preparation and in-vitro Evaluation of Topical Formulations based on Polystyrene-poly-2-hydroxyl methacrylate Nanoparticles
X. Wu, P. Griffin, G.J. Price & R.H. Guy. Mol Pharm, 6(5), 1449–1456, 2009.

Drug Delivery to the Skin from Sub-micron Polymeric Particle Formulations: Influence of Particle Size and Polymer Hydrophobicity
X. Wu, B. Biatry, C. Cazeneuve & R.H. Guy. Pharm Res, 26(8), 1995-2001, 2009.

Improved Bioequivalence Assessment of Topical Dermatological Drug Products using Dermatopharmacokinetics
B. N'Dri-Stempfer, W.C. Navidi, R.H.Guy & A.L.Bunge. Pharm Res, 26(2), 316-28, 2009.

Dermatopharmacokinetics of Betamethasone 17-valerate: Influence of Formulation Viscosity and Skin Surface Cleaning Procedure
S. Wiedersberg, C.S. Leopold & R.H.Guy. Eur J Pharm Biopharm, 71(2), 362-366, 2009.

Dye Diffusion from Microcapsules with Different Shell Thickness into Mammalian Skin
H.N. Yow, X. Wu, A.F. Routh & R.H. Guy. Eur J Pharm Biopharm, 72(1), 62-68, 2009.

Pharmacodynamics and Dermatopharmacokinetics of Betamethasone 17-valerate: Assessment of Topical Bioavailability
S. Wiedersberg, A. Naik, C.S. Leopold & R.H. Guy. Brit J Dermatol, 160(3), 676-86, 2009.

Transcutaneous Immunisation assisted by low-frequency Ultrasound
A. Dahlan, H.O. Alpar, P. Stickings, D. Sesardic & S. Murdan. Int J Pharm, 368(1-2), 123-128, 2009.

Dermatopharmacokinetics: Factors Influencing Drug Clearance from the Stratum Corneum
S. Nicoli, A.L. Bunge, M.B. Delgado-Charro, & R.H. Guy. Pharm Res, 26(4), 2009.

Effects of Various Vehicles on Skin Hydration in-vivo
S. Wiedersberg, C.S. Leopold & R.H. Guy. Skin Pharmacol Physiol, 22, 128-130, 2009.


Increased Basal Transepidermal Water Loss leads to Elevation of some but not all Stratum Corneum Serine Proteases
R. Vögeli, A.V. Rawlings, S. Doppler & T. Schreier. Int J Cosmet Sci, 30, 435-442, 2008.

A few Aspects of Transonychial Water Loss (TOWL): Inter-individual, and Intra-individual Inter-finger, Inter-hand and Inter-day Variabilities, and the Influence of Nail Plate Hydration, Filing and Varnish
S. Murdan, D. Hinsu & M. Guimier. Eur J Pharm Biopharm, 70, 684-689, 2008.

The Determination of Stratum Corneum Thickness: An Alternative Approach
L.M. Russell, S. Wiedersberg & M.B Delgado-Charro. Eur J Pharm Biopharm, 69(3), 2008.

Biophysical Techniques to Characterise Skin Permeability
M. Machado, T. Salgado, H. Ribeiro, J. Hadgraft & M.E. Lane. Skin Forum. London, UK, 2008.

Instruments for Measuring Skin Toxicity
H. Taylor: Principles and Practice of Skin Toxicology (Editors: R.P. Chilcott & S. Price), Ch12, 201–220, 2008.

Guidance for TEWL Measurements
H. Taylor. In: Principles and Practice of Skin Toxicology, (R.P. Chilcott & S. Price eds). Print ISBN: 9780470511725 Online ISBN: 9780470773093. John Wiley & Sons Ltd 2008.

Novel Beads made of Alpha-cyclodextrin and Oil for Topical Delivery of a Lipophilic Drug
L. Trichard, M.B. Delgado-Charro, R.H. Guy, E. Fattal & A. Bochot. Pharm Res, 25(2), 2008.

Microbial Colonization of an In-vitro Model of a Tissue-engineered Human Skin Equivalent - a Novel Approach
D.B. Holland, R.A. Bojar, A.H.T. Jeremy, E. Ingham & K.T. Holland. FEMS Microbiology Letters, 279(1), 2008.


Determination of Subclinical Changes of Barrier Function
V. Charbonnier, M. Paye & H.I. Maibach. Dermatotoxicology, Seventh Edition, 64, 561–568. Edited by H. Zhai, K-P. Wilhelm, H.I. Maibach. Informa Healthcare 2007.

Pharmaceutical Compositions Comprising Metals for Modulating Epithelial Cell-to-cell Adhesion
S.J. Ward, A. Macgowan, M.J. Cork, J. Hadgraft, M.E. Lane, A. Davis & R Guy. Patent WO/2007/020479.

Measurements of Trans-onychial Water Loss (TOWL) using AquaFlux
D. Hinsu & S. Murdan. AAPS Journal, 9, S2, Abstract T3182, 2007.

Profiling of Serine Protease Activities in Human Stratum Corneum and Detection of a Stratum Corneum Tryptase-like Enzyme
R. Vögeli, A.V. Rawlings, S. Doppler, J. Heiland & T. Schreier. Int J Cosmet Sci, 29(3), 191-200, 2007.

Measurements of Trans-onychial Water Loss (TOWL) using a Specially Designed Cap with the AquaFlux
D. Hinsu, M. Guimier & S. Murdan. Pharmaceutical Posters on the Web, 2(2), 2007.

Applications of Iontophoresis in Sports Medicine
J-P. Sylvestre, PhD thesis, University of Bath, Department of Pharmacy and Pharmacology, 2007.

Estudi de la Formació de Nano-emulsions de Fase Externa Aquosa i Solubilització de F àrmacs Lipòfils
N. Sadurní Gràcia, PhD Thesis, Universitat de Barcelona. ISBN B.19402-2007 / 978-84-690-4894-8, 2007.


Permeation of 4-cyanophenol and Methyl Paraben from Powder and Saturated Aqueous Solution through Silicone Rubber Membranes and Human Skin
W.J. Romonchuk & A.L. Bunge. J Pharm Sci, 95(11), 2526 - 2533, 2006.


Closed-chamber and Open-chamber TEWL Measurement: A Comparison of Dermalab and AquaFlux AF102 Instruments
C. Jones, S. Bennett & J.R. Matheson. Skin Res Tech (Abstract) 11(4): 296, 2005.

Comparison of Three TEWL Instruments for In-vitro and In-vivo Measurements
W. Tian. Skin Res Tech (Abstract) 11(4): 299, 2005.

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