List of AquaFlux User Publications

2012

Ability to Estimate Relative Percutaneous Penetration via a Surrogate Maker – Trans Epidermal Water Loss?
X. Hui, R. Elkeeb, H. Chan & H.I. Maibach. Skin Res Tech, 18(1), 108–13, 2012. (More..).

Differences in Susceptibility to Oxidative Stress in the Skin of Japanese and French Subjects and Physiological Characteristics of Their Skin.
Y. Yamashita, Y. Okano, T. Ngo, P. Buche, A. Sirvent, F. Girard & H. Masaki. Skin Pharmacol Physiol, 25, 78-85, 2012). (More..).

Effect of Y-Cyclodextrin on the In Vitro Skin Permeation of a Steroidal Drug from Nanoemulsions: Impact of Experimental Setup.
V. Klang, S. Haberfeld, A. Hartl & C. Valenta. Int J Pharm, 423(2), 535–542, 2012. (More..).

2011

In Vitro vs. In Vivo Tape Stripping: Validation of the Porcine Ear Model and Penetration Assessment of Novel Sucrose Stearate Emulsions.
V. Klang, J.C. Schwarz, B. Lenobel, M. Nadj, J. Auböck, M. Wolzt & C. Valenta. Eur J Pharm Biopharm, in press, 2011. (More..).

Time-Correlated Single Photon Counting for Simultaneous Monitoring of Zinc Oxide Nanoparticles and NAD(P)H in Intact and Barrier-Disrupted Volunteer Skin.
L.L. Lin, J.E. Grice, M.K. Butler, A.V. Zvyagin, W. Becker, T.A. Robertson, H.P. Soyer, M.S. Roberts & T.W. Prow. Pharm Res, 28(11), 2920-30, 2011. (More..).

Gold Nanoparticle Penetration and Reduced Metabolism in Human Skin by Toluene.
H.I. Labouta, D.C. Liu, L.L. Lin, M.K. Butler, J.E. Grice, A.P. Raphael, T. Kraus, L.K. El-Khordagui, H.P. Soyer, M.S. Roberts, M. Schneider & T.W. Prow. Pharm Res, 28(11), 2931-44, 2011. (More..).

Modification of the Conformational Skin Structure by Treatment with Liposomal Formulations and its Correlation to the Penetration Depth of Aciclovir.
A. Hasanovic, R. Winkler, G.P. Resch & C. Valenta. Eur J Pharm Biopharm, in press, 79(1), 76-81, 2011. (More..).

The Effect of Aqueous Cream BP on the Skin Barrier in Volunteers with a Previous History of Atopic Dermatitis.
S.G. Danby, T. Al-Enezi, A. Sultan, J. Chittock, K. Kennedy & M.J. Cork. Brit J Dermatol,165(2), 329-34, 2011. (More..).

Influence of Aqueous Cream on Corneocyte Size, Maturity, Skin Protease Activity, Protein Content and Trans-Epidermal Water Loss.
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. Brit J Dermatol, 164, 1304–1310, 2011. (More..).

Semi-solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems.
V. Klang, J.C. Schwarz, N. Matsko, E. Rezvani, N. El-Hagin, M. Wirth & C. Valenta. Pharmaceutics, 3(2), 275-306, 2011. (More..).

Infant Skin-cleansing Product versus Water: A Pilot Randomized, Assessor-blinded Controlled Trial.
T. Lavender, C. Bedwell, E. O'Brien, M.J. Cork, M. Turner & A. Hart. BMC Pediatrics, 11:35, 2011. (More..).

Depth Profiling of Stratum Corneum Biophysical and Molecular Properties.
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. Brit J Dermatol, 164(5), 957–965, 2011. (More..).

Facilitating in vitro Tape Stripping: Application of Infrared Densitometry for Quantification of Porcine Stratum Corneum Proteins.
V. Klang, J.C. Schwarz, A. Hartl & C. Valenta. Skin Pharmacol Physiol, 24(5), 256-268, 2011. (More..).

Les Adaptations climatiques chez les squamates.
A. Dupoué, Master 2 Écophysiologie et Éthologie, Université de Strasbourg (2011). (More..).

Visualization, Dermatopharmacokinetic Analysis and Monitoring the Conformational Effects of a Microemulsion Formulation in the Skin Stratum Corneum.
R.M. Hathout, S. Mansour, A.S. Geneidi & N.D. Mortada. Journal of Colloid and Interface Science, 354(1), 124-130, 2011. (More..).

2010

Assessment of Cumulative Exposure to UVA through Study of Asymmetric Facial Skin Damage.
S. Mac-Mary, J-M. Sainthillier, A. Jeudy, C. Sladen, C. Williams, M. Bell & P. Humbert. Clin Interv Aging, 5, 277-284, 2010. (More..).

Disposition of Charged Nanoparticles after their Topical Application to the Skin.
X. Wu, K. Landfester, A. Musyanovych & R.H. Guy. Skin Pharmacol Physiol, 23(3), 117-123, 2010. (More..).

Effect of Aqueous Cream BP on human stratum corneum in vivo.
M. Tsang & R.H. Guy. Brit J Dermatol, 163, 954–958, 2010. (More..).

Formulation and Delivery of Topically Applied Drugs for the Treatment of Atopic Eczema and other Related Diseases.
M. Tsang, PhD Thesis, University of Bath 2010. (More..).

Extraction and quantification of amino acids in human stratum corneum in vivo.
J.-P. Sylvestre, C.C. Bouissou, R.H. Guy & M.B. Delgado-Charro. Brit J Dermatol, 163, 458–465, 2010. (More..).

Superior Effect of Isostearyl Isostearate on Improvement in Stratum Corneum Water Permeability Barrier Function as Examined by the Plastic Occlusion Stress Test.
G. Pennick, S. Harrison, D. Jones & A.V. Rawlings. Int J Cosmet Sci, 32(4), 304–312, 2010. (More..).

Filaggrin Loss-of-function Mutations are Associated with Early-onset Eczema, Eczema Severity and Transepidermal Water Loss at 3 Months of Age.
C. Flohr, K. England, S. Radulovic, W.H.I. McLean, L.E. Campbell, J. Barker, M. Perkin & G. Lack. Brit J Dermatol, 163(6), 1333–1336, 2010. (More..).

The Relationship between Transepidermal Water Loss and Skin Permeability.
M. Machado, T.M. Salgado, J. Hadgraft & M.E. Lane. Int J Pharm, 384, 73-77, 2010. (More..).

Correlation of Transepidermal Water Loss with Skin Barrier Properties In-vitro: Comparison of Three Evaporimeters.
R. Elkeeb, X. Hui, H. Chan, L. Tien & H.I. Maibach. Skin Res Tech, 16(1), 9–15, 2010. (More..).

Effects of Microneedle Length, Density, Insertion Time and Multiple Applications on Human Skin Barrier Function: Assessments by Transepidermal Water Loss.
Y.A. Gomaa, D.I.J. Morrow, M.J. Garland, R.F. Donnelly, L.K. El-Khordagui & V.M. Meidan. Toxicology in Vitro, 24(7), 1971-1978, 2010. (More..).

Ageing Appearance in China: Biophysical Profile of Facial Skin and its Relationship to Perceived Age.
A.E. Mayes, P.G. Murray, D.A. Gunn, C.C. Tomlin, S.D. Catt, Y.B. Wen, L.P. Zhou, H.Q. Wang, M. Catt & S.P. Granger. J Eur Acad Dermatol Venereol. 24(3), 341-8, 2010. (More..).

2009

4-amidino Benzylamines for Cosmetic and/or Dermatological Use.
R. Vögeli, H. Ziegler & M. Gempeler, Patent WO/2009/026949. (More..).

An Investigation into the Combination of low Frequency Ultrasound and Liposomes on Skin Permeability.
A. Dahlan, H.O. Alpar & S. Murdan. Int J Pharm, 379, 139-142, 2009. (More..).

Transepidermal Water Loss for Probing Full-thickness Skin Barrier Function: Correlation with Tritiated Water Flux, Sensitivity to Punctures and Diverse Surfactant Exposures.
E. Elmahjoubi, Y. Frum, G.M. Eccleston, S.C. Wilkinson & V.M. Meidan. Toxicology in Vitro, 23(7), 1429-35, 2009. (More..).

In-vivo Transungual Iontophoresis: Effect of DC Current Application on Ionic Transport and on Transonychial Water Loss.
J. Dutet, & M.B. Delgado-Charro. Journal of Controlled Release, 140(2), 117-25, 2009. (More..).

Measuring Transepidermal Water Loss: Comparative In-vivo Study of Condenser-chamber, Unventilated-chamber and Open-chamber Systems.
S. Farahmand, L. Tien, X. Hui & H.I. Maibach. Skin Res Tech, 15(4), 392-398, 2009. (More..).

Preparation and In-vitro Evaluation of Topical Formulations based on Polystyrene-poly-2-hydroxyl methacrylate Nanoparticles.
X. Wu, P. Griffin, G.J. Price & R.H. Guy. Mol Pharm, 6(5), 1449–1456, 2009. (More..).

Drug Delivery to the Skin from Sub-micron Polymeric Particle Formulations: Influence of Particle Size and Polymer Hydrophobicity.
X. Wu, B. Biatry, C. Cazeneuve & R.H. Guy. Pharm Res, 26(8), 1995-2001, 2009. (More..).

Improved Bioequivalence Assessment of Topical Dermatological Drug Products using Dermatopharmacokinetics.
B. N'Dri-Stempfer, W.C. Navidi, R.H.Guy & A.L.Bunge. Pharm Res, 26(2), 316-28, 2009. (More..).

Dermatopharmacokinetics of Betamethasone 17-valerate: Influence of Formulation Viscosity and Skin Surface Cleaning Procedure.
S. Wiedersberg, C.S. Leopold & R.H.Guy. Eur J Pharm Biopharm, 71(2), 362-366, 2009. (More..).

Dye Diffusion from Microcapsules with Different Shell Thickness into Mammalian Skin.
H.N. Yow, X. Wu, A.F. Routh & R.H. Guy. Eur J Pharm Biopharm, 72(1), 62-68, 2009. (More..).

Pharmacodynamics and Dermatopharmacokinetics of Betamethasone 17-valerate: Assessment of Topical Bioavailability.
S. Wiedersberg, A. Naik, C.S. Leopold & R.H. Guy. Brit J Dermatol, 160(3), 676-86, 2009. (More..).

Transcutaneous Immunisation Assisted by low-frequency Ultrasound.
A. Dahlan, H.O. Alpar, P. Stickings, D. Sesardic & S. Murdan. Int J Pharm, 368(1-2), 123-128, 2009. (More..).

Dermatopharmacokinetics: Factors Influencing Drug Clearance from the Stratum Corneum.
S. Nicoli, A.L. Bunge, M.B. Delgado-Charro, & R.H. Guy. Pharm Res, 26(4), 2009. (More..).

Effects of Various Vehicles on Skin Hydration In-vivo.
S. Wiedersberg, C.S. Leopold & R.H. Guy. Skin Pharmacol Physiol, 22, 128-130, 2009. (More..).

2008

Increased Basal Transepidermal Water Loss leads to Elevation of some but not all Stratum Corneum Serine Proteases.
R. Vögeli, A.V. Rawlings, S. Doppler & T. Schreier. Int J Cosmet Sci, 30, 435-442, 2008. (More..).

Serine Proteases, Skin Function and Homeostasis.
R. Vögeli, A.V. Rawlings, J.W. Fluhr, S. Doppler & T. Schreier. 25th IFSCC Congress, 6-9 October, Barcelona, Spain, 2008.

A few Aspects of Transonychial Water Loss (TOWL): Inter-individual, and Intra-individual Inter-finger, Inter-hand and Inter-day Variabilities, and the Influence of Nail Plate Hydration, Filing and Varnish.
S. Murdan, D. Hinsu & M. Guimier. Eur J Pharm Biopharm, 70, 684-689, 2008. (More..).

The Determination of Stratum Corneum Thickness: An Alternative Approach.
L.M. Russell, S. Wiedersberg & M.B Delgado-Charro. Eur J Pharm Biopharm, 69(3), 2008. (More..).

Biophysical Techniques to Characterise Skin Permeability.
M. Machado, T. Salgado, H. Ribeiro, J. Hadgraft & M.E. Lane. Skin Forum. London, UK, 2008. (More..).

Guidance for TEWL Measurements.
H. Taylor. In: Principles and Practice of Skin Toxicology, (R.P. Chilcott & S. Price eds). Print ISBN: 9780470511725 Online ISBN: 9780470773093. John Wiley & Sons Ltd 2008. (More..).

Novel Beads made of Alpha-cyclodextrin and Oil for Topical Delivery of a Lipophilic Drug.
L. Trichard, M.B. Delgado-Charro, R.H. Guy, E. Fattal & A. Bochot. Pharm Res, 25(2), 2008. (More..).

Microbial Colonization of an In-vitro Model of a Tissue-engineered Human Skin Equivalent - a Novel Approach.
D.B. Holland, R.A. Bojar, A.H.T. Jeremy, E. Ingham & K.T. Holland. FEMS Microbiology Letters, 279(1), 2008. (More..).

2007

Determination of Subclinical Changes of Barrier Function.
V. Charbonnier, M. Paye & H.I. Maibach. Dermatotoxicology, Seventh Edition, 64, 561–568. Edited by H. Zhai, K-P. Wilhelm, H.I. Maibach. Informa Healthcare 2007. (More..).

Pharmaceutical Compositions Comprising Metals for Modulating Epithelial Cell-to-cell Adhesion.
S.J. Ward, A. Macgowan, M.J. Cork, J. Hadgraft, M.E. Lane, A. Davis & R Guy. Patent WO/2007/020479. (More..).

Measurements of Trans-onychial Water Loss (TOWL) using AquaFlux.
D. Hinsu & S. Murdan. AAPS Journal, 9, S2, Abstract T3182, 2007. (More..).

Profiling of Serine Protease Activities in Human Stratum Corneum and Detection of a Stratum Corneum Tryptase-like Enzyme.
R. Vögeli, A.V. Rawlings, S. Doppler, J. Heiland & T. Schreier. Int J Cosmet Sci, 29(3), 191-200, 2007. (More..).

Measurements of Trans-onychial Water Loss (TOWL) using a Specially Designed Cap with the AquaFlux.
D. Hinsu, M. Guimier & S. Murdan. Pharmaceutical Posters on the Web, 2(2), 2007. (More..).

Applications of Iontophoresis in Sports Medicine.
J-P. Sylvestre, PhD thesis, University of Bath, Department of Pharmacy and Pharmacology, ( 2007). (More..).

Estudi de la Formació de Nano-emulsions de Fase Externa Aquosa i Solubilització de F àrmacs Lipòfils.
N. Sadurní Gràcia, PhD Thesis, Universitat de Barcelona. ISBN B.19402-2007 / 978-84-690-4894-8 (2007). (More..).

2006

2005

Closed-chamber and Open-chamber TEWL Measurement: A Comparison of Dermalab and AquaFlux AF102 Instruments.
C. Jones, S. Bennett & J.R. Matheson. Skin Res Tech (Abstract) 11(4): 296, 2005. (More..).

Comparison of Three TEWL Instruments for In-vitro and In-vivo Measurements.
W. Tian. Skin Res Tech (Abstract) 11(4): 299, 2005. (More..).