List of AquaFlux User Publications

2012

Ability to Estimate Relative Percutaneous Penetration via a Surrogate Maker – Trans Epidermal Water Loss?
X. Hui, R. Elkeeb, H. Chan & H.I. Maibach. Skin Res Tech, 18(1), 108–13, 2012. (More..).

2011

Time-Correlated Single Photon Counting For Simultaneous Monitoring Of Zinc Oxide Nanoparticles And NAD(P)H In Intact And Barrier-Disrupted Volunteer Skin.
L.L. Lin, J.E. Grice, M.K. Butler, A.V. Zvyagin, W. Becker, T.A. Robertson, H.P. Soyer, M.S. Roberts & T.W. Prow. Pharmaceutical Research, in press, 2011. (More..).

Gold Nanoparticle Penetration and Reduced Metabolism in Human Skin by Toluene.
H.I. Labouta, D.C. Liu, L.L. Lin, M.K. Butler, J.E. Grice, A.P. Raphael, T. Kraus, L.K. El-Khordagui, H.P. Soyer, M.S. Roberts, M. Schneider & T.W. Prow. Pharmaceutical Research, in press, 2011. (More..).

Modification of the Conformational Skin Structure by Treatment with Liposomal Formulations and its Correlation to the Penetration Depth of Aciclovir.
A. Hasanovic, R. Winkler, G.P. Resch & C. Valenta. European Journal of Pharmaceutics and Biopharmaceutics, in press, 2011. (More..).

The Effect of Aqueous Cream BP on the Skin Barrier in Volunteers with a Previous History of Atopic Dermatitis.
S.G. Danby, T. Al-Enezi, A. Sultan, J. Chittock, K. Kennedy & M.J. Cork. Br J Dermatol. 165(2), 329-34, 2011. (More..).

Influence of Aqueous Cream on Corneocyte Size, Maturity, Skin Protease Activity, Protein Content and Trans-Epidermal Water Loss.
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. British Journal of Dermatology, 164, 1304–1310, 2011. (More..).

Semi-solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems.
V. Klang, J.C. Schwarz, N. Matsko, E. Rezvani, N. El-Hagin, M. Wirth & C. Valenta. Pharmaceutics 3(2), 275-306, 2011. (More..).

Infant Skin-cleansing Product versus Water: A Pilot Randomized, Assessor-blinded Controlled Trial.
T. Lavender, C. Bedwell, E. O'Brien, M.J. Cork, M. Turner & A. Hart. BMC Pediatrics, 11:35, 2011. (More..).

Depth Profiling of Stratum Corneum Biophysical and Molecular Properties.
D. Mohammed, P.J. Matts, J. Hadgraft & M.E. Lane. British Journal of Dermatology, 164(5), 957–965, 2011. (More..).

Facilitating in vitro Tape Stripping: Application of Infrared Densitometry for Quantification of Porcine Stratum Corneum Proteins.
V. Klang, J.C. Schwarz, A. Hartl & C. Valenta. Skin Pharmacol Physiol, 24(5), 256-268, 2011. (More..).

Visualization, Dermatopharmacokinetic Analysis and Monitoring the Conformational Effects of a Microemulsion Formulation in the Skin Stratum Corneum.
R.M. Hathout, S. Mansour, A.S. Geneidi & N.D. Mortada. Journal of Colloid and Interface Science, 354(1), 124-130, 2011. (More..).

2010

Assessment of Cumulative Exposure to UVA through Study of Asymmetric Facial Skin Damage.
S. Mac-Mary, J-M. Sainthillier, A. Jeudy, C. Sladen, C. Williams, M. Bell & P. Humbert. Clin Interv Aging, 5, 277-284, 2010. (More..).

Disposition of Charged Nanoparticles after their Topical Application to the Skin.
X. Wu, K. Landfester, A. Musyanovych & R.H. Guy. Skin Pharmacol Physiol 23(3), 117-123, 2010. (More..).

Effect of Aqueous Cream BP on human stratum corneum in vivo.
M. Tsang & R.H. Guy. British Journal of Dermatology, 163, 954–958, 2010. (More..).

Formulation and Delivery of Topically Applied Drugs for the Treatment of Atopic Eczema and other Related Diseases.
M. Tsang, PhD Thesis, University of Bath 2010. (More..).

Extraction and quantification of amino acids in human stratum corneum in vivo.
J.-P. Sylvestre, C.C. Bouissou, R.H. Guy & M.B. Delgado-Charro. British Journal of Dermatology, 163, 458–465, 2010. (More..).

Superior Effect of Isostearyl Isostearate on Improvement in Stratum Corneum Water Permeability Barrier Function as Examined by the Plastic Occlusion Stress Test.
G. Pennick, S. Harrison, D. Jones & A.V. Rawlings. International Journal of Cosmetic Science, 32(4), 304–312, 2010. (More..).

Filaggrin Loss-of-function Mutations are Associated with Early-onset Eczema, Eczema Severity and Transepidermal Water Loss at 3 Months of Age.
C. Flohr, K. England, S. Radulovic, W.H.I. McLean, L.E. Campbell, J. Barker, M. Perkin & G. Lack. British Journal of Dermatology 163(6), 1333–1336, 2010. (More..).

The Relationship between Transepidermal Water Loss and Skin Permeability.
M. Machado, T.M. Salgado, J. Hadgraft & M.E. Lane. International Journal of Pharmaceutics 384, 73-77, 2010. (More..).

Correlation of Transepidermal Water Loss with Skin Barrier Properties In-vitro: Comparison of Three Evaporimeters.
R. Elkeeb, X. Hui, H. Chan, L. Tien & H.I. Maibach. Skin Research and Technology. 16(1), 9–15, 2010. (More..).

Effects of Microneedle Length, Density, Insertion Time and Multiple Applications on Human Skin Barrier Function: Assessments by Transepidermal Water Loss.
Y.A. Gomaa, D.I.J. Morrow, M.J. Garland, R.F. Donnelly, L.K. El-Khordagui & V.M. Meidan. Toxicology in Vitro, 24(7), 1971-1978, 2010. (More..).

Ageing Appearance in China: Biophysical Profile of Facial Skin and its Relationship to Perceived Age.
A.E. Mayes, P.G. Murray, D.A. Gunn, C.C. Tomlin, S.D. Catt, Y.B. Wen, L.P. Zhou, H.Q. Wang, M. Catt & S.P. Granger. J Eur Acad Dermatol Venereol. 24(3), 341-8, 2010. (More..).

2009

4-amidino Benzylamines for Cosmetic and/or Dermatological Use.
R. Vögeli, H. Ziegler & M. Gempeler, Patent WO/2009/026949. (More..).

An Investigation into the Combination of low Frequency Ultrasound and Liposomes on Skin Permeability.
A. Dahlan, H.O. Alpar & S. Murdan. International Journal of Pharmaceutics 379, 139-142, 2009. (More..).

Transepidermal Water Loss for Probing Full-thickness Skin Barrier Function: Correlation with Tritiated Water Flux, Sensitivity to Punctures and Diverse Surfactant Exposures.
E. Elmahjoubi, Y. Frum, G.M. Eccleston, S.C. Wilkinson & V.M. Meidan. Toxicology in Vitro, 23(7), 1429-35, 2009. (More..).

In-vivo Transungual Iontophoresis: Effect of DC Current Application on Ionic Transport and on Transonychial Water Loss.
J. Dutet, & M.B. Delgado-Charro. Journal of Controlled Release, 140(2), 117-25, 2009. (More..).

Measuring Transepidermal Water Loss: Comparative In-vivo Study of Condenser-chamber, Unventilated-chamber and Open-chamber Systems.
S. Farahmand, L. Tien, X. Hui & H.I. Maibach. Skin Research and Technology, 15(4), 392-398, 2009. (More..).

Preparation and In-vitro Evaluation of Topical Formulations based on Polystyrene-poly-2-hydroxyl methacrylate Nanoparticles.
X. Wu, P. Griffin, G.J. Price & R.H. Guy. Molecular Pharmaceutics, 6(5), 1449–1456, 2009. (More..).

Drug Delivery to the Skin from Sub-micron Polymeric Particle Formulations: Influence of Particle Size and Polymer Hydrophobicity.
X. Wu, B. Biatry, C. Cazeneuve & R.H. Guy. Pharmaceutical Research, 26(8), 1995-2001, 2009. (More..).

Improved Bioequivalence Assessment of Topical Dermatological Drug Products using Dermatopharmacokinetics.
B. N'Dri-Stempfer, W.C. Navidi, R.H.Guy & A.L.Bunge. Pharmaceutical Research, 26(2), 316-28, 2009. (More..).

Dermatopharmacokinetics of Betamethasone 17-valerate: Influence of Formulation Viscosity and Skin Surface Cleaning Procedure.
S. Wiedersberg, C.S. Leopold & R.H.Guy. European Journal of Pharmaceutics and Biopharmaceutics, 71(2), 362-366, 2009. (More..).

Dye Diffusion from Microcapsules with Different Shell Thickness into Mammalian Skin.
H.N. Yow, X. Wu, A.F. Routh & R.H. Guy. European Journal of Pharmaceutics and Biopharmaceutics, 72(1), 62-68, 2009. (More..).

Pharmacodynamics and Dermatopharmacokinetics of Betamethasone 17-valerate: Assessment of Topical Bioavailability.
S. Wiedersberg, A. Naik, C.S. Leopold & R.H. Guy. British Journal of Dermatology, 160(3), 676-86, 2009. (More..).

Transcutaneous Immunisation Assisted by low-frequency Ultrasound.
A. Dahlan, H.O. Alpar, P. Stickings, D. Sesardic & S. Murdan. International Journal of Pharmaceutics, 368(1-2), 123-128, 2009. (More..).

Dermatopharmacokinetics: Factors Influencing Drug Clearance from the Stratum Corneum.
S. Nicoli, A.L. Bunge, M.B. Delgado-Charro, & R.H. Guy. Pharmaceutical Research, 26(4), 2009. (More..).

Effects of Various Vehicles on Skin Hydration In-vivo.
S. Wiedersberg, C.S. Leopold & R.H. Guy. Skin Pharmacol Physiol, 22, 128-130, 2009. (More..).

2008

Increased Basal Transepidermal Water Loss leads to Elevation of some but not all Stratum Corneum Serine Proteases.
R. Vögeli, A.V. Rawlings, S. Doppler & T. Schreier. International Journal of Cosmetic Science, 30, 435-442, 2008. (More..).

Serine Proteases, Skin Function and Homeostasis.
R. Vögeli, A.V. Rawlings, J.W. Fluhr, S. Doppler & T. Schreier. 25th IFSCC Congress, 6-9 October, Barcelona, Spain, 2008.

A few Aspects of Transonychial Water Loss (TOWL): Inter-individual, and Intra-individual Inter-finger, Inter-hand and Inter-day Variabilities, and the Influence of Nail Plate Hydration, Filing and Varnish.
S. Murdan, D. Hinsu & M. Guimier. European Journal of Pharmaceutics and Biopharmaceutics, 70, 684-689, 2008. (More..).

The Determination of Stratum Corneum Thickness: An Alternative Approach.
L.M. Russell, S. Wiedersberg & M.B Delgado-Charro. European Journal of Pharmaceutics and Biopharmaceutics, 69(3), 2008. (More..).

Biophysical Techniques to Characterise Skin Permeability.
M. Machado, T. Salgado, H. Ribeiro, J. Hadgraft & M.E. Lane. Skin Forum. London, UK, 2008. (More..).

Guidance for TEWL Measurements.
H. Taylor. In: Principles and Practice of Skin Toxicology, (R.P. Chilcott & S. Price eds). Print ISBN: 9780470511725 Online ISBN: 9780470773093. John Wiley & Sons Ltd 2008. (More..).

Novel Beads made of Alpha-cyclodextrin and Oil for Topical Delivery of a Lipophilic Drug.
L. Trichard, M.B. Delgado-Charro, R.H. Guy, E. Fattal & A. Bochot. Pharmaceutical Research, 25(2), 2008. (More..).

Microbial Colonization of an In-vitro Model of a Tissue-engineered Human Skin Equivalent - a Novel Approach.
D.B. Holland, R.A. Bojar, A.H.T. Jeremy, E. Ingham & K.T. Holland. FEMS Microbiology Letters, 279(1), 2008. (More..).

2007

Pharmaceutical Compositions Comprising Metals for Modulating Epithelial Cell-to-cell Adhesion.
S.J. Ward, A. Macgowan, M.J. Cork, J. Hadgraft, M.E. Lane, A. Davis & R Guy. Patent WO/2007/020479. (More..).

Measurements of Trans-onychial Water Loss (TOWL) using AquaFlux.
D. Hinsu & S. Murdan. AAPS Journal, 9, S2, Abstract T3182, 2007. (More..).

Profiling of Serine Protease Activities in Human Stratum Corneum and Detection of a Stratum Corneum Tryptase-like Enzyme.
R. Vögeli, A.V. Rawlings, S. Doppler, J. Heiland & T. Schreier. International Journal of Cosmetic Science, 29(3), 191-200, 2007. (More..).

Measurements of Trans-onychial Water Loss (TOWL) using a Specially Designed Cap with the AquaFlux.
D. Hinsu, M. Guimier & S. Murdan. Pharmaceutical Posters on the Web, 2(2), 2007. (More..).

Applications of Iontophoresis in Sports Medicine.
J-P. Sylvestre, PhD thesis, University of Bath, Department of Pharmacy and Pharmacology, ( 2007). (More..).

Estudi de la Formació de Nano-emulsions de Fase Externa Aquosa i Solubilització de F àrmacs Lipòfils.
N. Sadurní Gràcia, PhD Thesis, Universitat de Barcelona. ISBN B.19402-2007 / 978-84-690-4894-8 (2007). (More..).

2006

2005

Closed-chamber and Open-chamber TEWL Measurement: A Comparison of Dermalab and AquaFlux AF102 Instruments.
C. Jones, S. Bennett & J.R. Matheson. Skin Research and Technology (Abstract) 11(4): 296, 2005. (More..).

Comparison of Three TEWL Instruments for In-vitro and In-vivo Measurements.
W. Tian. Skin Research and Technology (Abstract) 11(4): 299, 2005. (More..).